Neurogenerative Diseases
One of our key research initiatives involves developing an innovative neuroelectrical engineering strategy to create a human vascularized brain-on-electronics. This research endeavor integrates the co-culture of neuronal cells and vasculature with advanced electrode-embedded culture platform, aiming to precisely analyze amyloid fibril pathology within a pathophysiologically relevant tissue environment and to enable real-time monitoring of neuronal degeneration through electrical interrogation techniques.
Neurodegenerative disease modelig
A Parkinson’s disease model established byexposing 3D vascularized midbrain tissue to α-syn fibrils.
Papers of interest
Alim, A., Baek, Y., Lee, M. et al. Microengineering of the capillary interface of midbrain dopaminergic neurons to study Parkinson’s disease vascular alterations. Commun Eng 5, 23 (2026)
Baek Y, Alim A, Dong Y, Olabi T, Paek J, Lee M. Lipid Acyl Chain-Driven α-Synuclein Fibril Polymorphisms and Neuronal Pathologies. ACS Chem Neurosci. (2026)
Pediaditakis, I., Kodella, K.R., Manatakis, D.V. et al. Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption. Nat Commun 12, 5907 (2021).