JPaek Lab
Research aim of our lab is developing unconventional organoid systems and organs-on-chips for biomedical and pharmaceutical applications.
The research focus also extends to the creation of microphysiological systems integrated with microengineered devices to investigate the impact of biophysical signals on human health and disease.
To this end, three immediate topics are
- Microengineered human organoids-on-chips for studying diverse
lung diseases
- Tissue-engineered 3D models of neurodegenerative diseases
- Biological neural networks emulating the human intellectual
decision-making process
ABOUT
Dr. Jay Jungwook Paek
is currently an assistant professor
in the Department of Electrical and Computer Engineering
at State University of New York at Binghamton.
Jay Paek is passionate about combining multiple engineering approaches to reverse engineer complex living systems for improving human health and wellbeing.
In particular, Jay Paek is interested in developing microphysiological systems
based on organ-on-a-chip and organoid technologies to study disease processes in the human respiratory and vascular systems.
Previously, Jay Paek was a research associate in the` Department of Bioengineering at University of Pennsylvania, where he worked on in vitro modeling of human tissues and organs.
Prior to his postdoctoral work, Jay received his Ph.D. in Electrical Engineering from Iowa State University with his primary research centered on the design, fabrication, and application of bio-inspired elastomeric microsystems.
PUBLICATIONS
Paek J, Teegala LR, Alisafaei F, Alim A, Song JW, Park SE, Chang J, Liu H, Kim BJ, Ryeom S, Shenoy V, Clair GC, Thodeti C, Paruchuri SM, Huh DD. Mechanical force-induced tissue remodelling in a clinically relevant microphysiological model of asthmatic human lungs. Nat Biomed Eng. (2026)
Alim A, Baek Y, Lee M, Paek J. Microengineering of the capillary interface of midbrain dopaminergic neurons to study Parkinson's disease vascular alterations. Commun Eng. 10, 5(1):23 (2026)
Baek Y, Alim A, Dong Y, Olabi T, Paek J, Lee M. Lipid Acyl Chain-Driven α-Synuclein Fibril Polymorphisms and Neuronal Pathologies. ACS Chem Neurosci. 1;17(7):1286-1302 (2026)
Liu H, Noguera-Ortega E, Dong X, Lee WD, Chang J, Aydin SA, Li Y, Shin Y, Shi X, Liousia M, Martinez MC, Brotman JJ, Kim S, Chen Z, Wang A, Ou Z, Paek J, Park JY, Liu A, Hu H, Xiao Z, Racca DM, Kim SJ, Worthen GS, Guo W, Puré E, Kang T, Rabinowitz JD, Wherry EJ, Moon EK, Albelda SM, Huh DD. A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors. Nature Biotechnol. 44(6), 959-975 (2026)
Sunghee E. Park, Shawn Kang, Jungwook Paek, Andrei Georgescu, Alex Yi, and Dongeun Huh, "Geometric engineering of organoid culture for enhanced organogenesis in a dish," Nat Methods, 19, 1449-1460 (2022)
Jungwook Paek, Joseph W. Song, Ehsan Ban, Yuma Morimitsu, Chinedum O. Osuji, Vivek B. Shenoy, and Dan Dongeun Huh, "Soft robotic constrictor for in vitro modeling of dynamic tissue compression," Scientific Reports, 11, 16478 (2021)
Jungwook Paek, Sunghee E. Park, Qiaozhi Lu, Kyu-Tae Park, Minseon Cho, Jeong Min Oh, Keon Woo Kwon, Yoon-suk Yi, Joseph W. Song, Hailey I. Edelstein, Jeff Ishibashi, Wenli Yang, Jacob W. Myerson, Raisa Y. Kiseleva, Pavel Aprelev, Elizabeth D. Hood, Dwight Stambolian, Patrick Seale, Vladimir R. Muzykantov, and Dongeun Huh, "Microphysiological engineering of self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues," ACS Nano, 13(7), 7627-7643 (2019)
News&Events
Jun. 2026
Our Nature Biomedical Engineering paper has been featured by Watson College News.
Apr. 2026
Our Nature Communication Engineering paper has been featured by Watson College News.
Apr. 2026
Our Nature Communication Engineering paper was featured by Springer Nature in the video “How Parkinson’s Hurts Blood Circulation”
Feb. 2026
Congratulations to Anika Alim on her first publication in Nature Communication Engineering.
Oct. 2024
Congratulations to Anika Alim on her first oral presentation at the 2024 BMES Annual Meeting in Baltimore.
Sep. 2024
Our Parkinson's Disease-on-a-chip research has been featured by Watson College News.
Aug. 2024
Jungwook (Jay) Paek and his research team receive an R21 award from NIH NINDS for Parkinson's Disease Research.
May. 2023
Jungwook (Jay) Paek is the recipient of the BU's Transdisciplinary Area of Excellence Seed Grant for Lung fibrosis-on-a-chip Research.