JPaek Lab
Research aim of our lab is developing unconventional organoid systems and organs-on-chips for biomedical and pharmaceutical applications.
The research focus also extends to the creation of microphysiological systems integrated with microengineered devices to investigate the impact of biophysical signals on human health and disease.
​
To this end, four immediate topics are
- Microengineered human organoids-on-chips for studying diverse lung diseases
- Tissue-engineered 3D models of neurodegenerative diseases
- Microphysiological models of disease-induced vascular disorders,
- Biological neural networks to emulate the intellectual decision-making process in the human brain.
ABOUT
Dr. Jay Jungwook Paek
​
is currently an assistant professor
in the Department of Electrical and Computer Engineering
at State University of New York at Binghamton.
Jay Paek is passionate about combining multiple engineering approaches to reverse engineer complex living systems for improving human health and wellbeing.
​
In particular, Jay Paek is interested in developing microphysiological systems
based on organ-on-a-chip and organoid technologies to study disease processes in the human respiratory and vascular systems.
​
Previously, Jay Paek was a research associate in the` Department of Bioengineering at University of Pennsylvania, where he worked on in vitro modeling of human tissues and organs.
​
Prior to his postdoctoral work, Jay received his Ph.D. in Electrical Engineering from Iowa State University with his primary research centered on the design, fabrication, and application of bio-inspired elastomeric microsystems.
​
PUBLICATIONS
Jungwook Paek, Lakshminarayan Reddy Teegala, Farid Alisafaei, Geremy C. Clair, Joseph W. Song, Sunghee E. Park, Charles K. Ansong, Mark J. Mondrinos, Vivek Shenoy, Charles Thodeti, Sailaja M. Paruchuri, and Dongeun Huh, "A microengineered model of mechanical force-induced tissue remodeling in human lungs," Submitted.
​
Sunghee E. Park, Shawn Kang, Jungwook Paek, Andrei Georgescu, Alex Yi, and Dongeun Huh, "Geometric engineering of organoid culture for enhanced organogenesis in a dish," Nat Methods, 19, 1449-1460 (2022)
​
Jungwook Paek, Joseph W. Song, Ehsan Ban, Yuma Morimitsu, Chinedum O. Osuji, Vivek B. Shenoy, and Dan Dongeun Huh, "Soft robotic constrictor for in vitro modeling of dynamic tissue compression," Scientific Reports, 11, 16478 (2021)
​
Jungwook Paek, Sunghee E. Park, Qiaozhi Lu, Kyu-Tae Park, Minseon Cho, Jeong Min Oh, Keon Woo Kwon, Yoon-suk Yi, Joseph W. Song, Hailey I. Edelstein, Jeff Ishibashi, Wenli Yang, Jacob W. Myerson, Raisa Y. Kiseleva, Pavel Aprelev, Elizabeth D. Hood, Dwight Stambolian, Patrick Seale, Vladimir R. Muzykantov, and Dongeun Huh, "Microphysiological engineering of self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues," ACS Nano, 13(7), 7627-7643 (2019)
​
Joseph W. Song, Jungwook Paek, Kyu-Tae Park, Jeongyun Seo, and Dan Dongeun Huh, "A bioinspired microfluidic model of liquid plug-induced mechanical airway injury," Biomicrofluidics, 12(4), 042211 (2018)
​
​​
